2 edition of delivery of bioactive proteins using biodegradable microspheres. found in the catalog.
delivery of bioactive proteins using biodegradable microspheres.
Barbara Ro isi n. Conway
by Aston University. Department of Pharmaceutical and Biological Sciences in Birmingham
Written in English
Thesis (PhD) - Aston University, 1996.
Introduction: Delivery systems in nanomedicine contribute to the improvements in wound healing, tissue regeneration, and anticancer pharmacological fields. Although various wound dressings have been used in wound care treatments, there is a great challenge in the wound management of ulcers, trauma, chronic wounds, and severe injury and burns, especially infected : Lina Fu. Microspheres are spherical & free flowing particles ranging in average particle size from 1 to 50 microns which consist of proteins or synthetic polymers. Some of the problems of overcome by producing control drug delivery system which enhances the therapeutic efficacy of a given drug. One such approach is using microspheres as carriers for drugs.
Microspheres and Microcapsules for Protein Delivery Current Pharmaceutical Design, , Vol. 19, No. 35 important to retain the stability and activity of proteins during en-capsulation process. Different microspheres and microcapsules, both hydrophilic and hydrophobic counterparts, were developed for . Nowadays, bioactive peptides are used for therapeutic applications and the selection of a carrier to deliver them is very important to increase the efficiency, absorption, release, bioavailability and consumer acceptance. The aim of this study was to develop and characterize chitosan-based films loaded with chitosan microparticles containing a bioactive peptide (sequence: KGYGGVSLPEW) with Cited by: 5.
The microspheres are characteristically free flowing powders consisting of proteins orsynthetic polymers, which are biodegradable in nature, andideally having a particle size less than micrometer. Novel Drug Delivery Systems are developed to address the challengesof drug development such as Bioavailability, Permeability & Poor solubility. Microspheres. Injectable, biodegradable microspheres form a successful system for parenteral drug delivery. Relying on micro-encapsulation process technologies developed in-house and through technology partnerships, InnoCore is capable of producing injectable microsphere formulations with controlled particle size (typically micron) that are suitable for sustained release of active.
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Out of all above-mentioned delivery routes parenteral delivery of proteins by biodegradable microspheres is the most suitable and preferred one till today because of several aspects already mentioned. A key factor in the design of injectable protein delivery systems is the Cited by: Jones, A.
S., Nguyen, T. H., Cleland, J. L., and Pearlman, R.,New delivery systems for recombinant proteins—practical issues from proof of concept to Cited by: Protein Delivery from Biodegradable Microspheres.
microspheres using a double-emulsion solvent extraction/evaporation technique. as applied to encapsulation of bioactive macromolecules. While in conventional systems the drug is usually released shortly after delivery and stops working after a brief period of time, biodegradable polymer offers a way to provide sustained release over a longer time, thus eliminating the need for multiple doses and ensuring sustained and controlled drug delivery over weeks or months.
To demonstrate that bioactive proteins can be incorporated and released from the photodegradable particles in the presence of cells, we entrapped a common and potent growth factor, TGF-β1, 29 within the microspheres.
TGF-β1 loaded particles, as well as blank particles, were delivered to plated PE25 cells, a reporter cell line that produces Cited by: 6. Crit Rev Ther Drug Carrier Syst.
;12(1) Biodegradable microspheres in drug delivery. Okada H(1), Toguchi H. Author information: (1)Pharmaceutical Development Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan. General aspects of biodegradable microspheres prepared from natural and synthesized polymers used in drug delivery systems are reviewed first from various Cited by: Chemoembolization using PLGA microspheres containing an angiogenesis inhibitor, TNP, resulted in dramatic regression of VX-2 carcinoma in rabbits.
The microsphere system using biodegradable polymers is very useful in designing controlled release delivery and targeted delivery to Cited by: Biodegradable Microspheres for Protein Deliver Article Literature Review in Journal of Controlled Release 90(3) August with Reads How we measure 'reads'.
Poly(lactic/glycolic acid) (PLGA) microspheres, containing (fluorescein isothiocyanate)-labeled bovine serum albumin and (fluorescein isothiocyanate)-labeled horseradish peroxidase, were prepared by a modified solvent evaporation method using a double emulsion.
The microspheres were spherical with diameters of 55–95 µm and encapsulated more Cited by: One of the microsphere topics that seems to be growing these days is biodegradability.
For those of you who are unfamiliar with the topic an excellent introductory article can be found in: Advance Drug Delivery Reviews 52 ()called “Biodegradable microspheres for vitreoretinal drug delivery.”” The article does a good job describing the advantages of the various polymers.
Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology. The selection first tackles biologically engineered microstructures and approaches to targeting bioactive Edition: 1.
absolute accuracy can be achieved by attaching bioactive molecule to liposome, bioerodible polymer, implants, monoclonal antibodies and various particulate. One such approach is using microspheres as carriers for drugs.
Microsphere can be used for the controlled release of File Size: 1MB. Aliphatic polyester biodegradable microspheres have been extensively studied for controlled and minimally invasive in situ protein delivery. However, they are commonly characterized by protein denaturation via acidic polyester degradation products, whereas their supraphysiologic modulus contributes to the inflammatory response upon implantation.
To address these limitations, low-melting Author: Dimitra A. Louka, Nathan Holwell, Brandon H. Thomas, Fei Chen, Brian G. Amsden. Advances in Drug Delivery Systems, 6 focuses on the progress in drug delivery systems as manifested in the fields of international pharmaceutics, polymer science, biotechnology, molecular biology, and cell biology.
The selection first tackles biologically engineered microstructures and approaches to targeting bioactive compounds. Bioactive glass is a new biodegradable carrier material, which can form alkaline substances gradually in vivore-lease.
It can be used to neutralize the acidity caused by degradation of PLGA, stabilize the protein in the drug release process. In this study, a novel exenatide loaded bioactive glass (BG)-PLGA microsphere were.
Chitin/PLGA blend microspheres as a biodegradable drug delivery system: A new delivery system for protein Fwu Long Mi, Shin Shing Shyu, Yi Mei Lin, Yu Bey Wu, Chih Kang Peng, Yi Hung Tsai Research output: Contribution to journal › ArticleCited by: emulsions, liposomes, microspheres) where preparation conditions are sometimes detrimental to proteins (e.g use of organic solvents), mild conditions are used in hydrogel preparation procedure.
Nevertheless, an initial burst release of proteins and peptides is one of the major challenges by using. Microspheres: as carrieres used for novel drug delivery system 45 (ferromagnetic)to be captured in microvessels and dragged into the adjuscent tissues by magnetic field of tesla.
Floating Microspheres(4)(8)(9): Gastro-retentive floating microspheres are low-density systems that have. Aliphatic polyester biodegradable microspheres have been extensively studied for controlled and minimally invasive in situ protein delivery.
However, they are commonly characterized by protein denaturation via acidic polyester degradation products, whereas their supraphysiologic modulus contributes to the inflammatory response upon : Dimitra A.
Louka, Nathan Holwell, Brandon H. Thomas, Fei Chen, Brian G. Amsden. For the past few decades, biodegradable polymers have been applied as carriers for controlled delivery of low molecular weight drugs as well as bioactive proteins [1,2,3,4,5].Biodegradable polymers, either synthetic or natural, are capable of being cleaved into biocompatible byproducts through chemical or enzyme-catalyzed by:.
A biodegradable polymeric system for peptide–protein delivery assembled with porous microspheres and nanoparticles, using an adsorption/infiltration process Sergio Alcalá-Alcalá, Zaida Urbán-Morlán, Irene Aguilar-Rosas, David Quintanar-Guerrero Laboratorio de Investigación y Posgrado en Tecnología Farmacéutica, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional.
Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to μm. Made up of polymeric, waxy, or other protective materials such as starches, gums, proteins, fats, and waxes and used as drug carrier matrices for drug delivery.
Microcapsules: micrometric reservoir systems Microspheres: micrometric matrix.Biodegradable dextran hydrogels for protein delivery applications 19 HEMA) (Fig.
1D). The degradation time could be varied from one day to more than three months, depending on the crosslink density, water content, type of ester group in the crosslinks and length of the lactate spacer.